Preparation of bonelike apatite composite for tissue engineering scaffold
نویسندگان
چکیده
A novel sponge composed of a poly (lactic acid) composite skeleton covered with bonelike apatite (b-HA) was produced via a particleleaching technique combined with a biomimetic processing. The sponge has a large porosity of w75% with large-sized pores and shows mechanical ductility. After incubation of human osteoblasts for 7 days, numerous cells attached to the surface of the skeleton, which was covered with b-HA. One result of the osteoclastic cell culture showed that the b-HA on the composite has excellent bioresorbability. The sponge is expected to be one of the promising candidates for bone tissue engineering scaffolds. q 2004 Elsevier Ltd. All rights reserved.
منابع مشابه
PLLA scaffolds with biomimetic apatite coating and biomimetic apatite/collagen composite coating to enhance osteoblast-like cells attachment and activity
Novel scaffolds composed of poly(L-lactic acid) (PLLA) skeleton covered with bonelike apatite or apatite/collagen composite were produced via a combined phase-separation technique and an accelerated biomimetic coating process. Saos-2 osteoblast-like cells were used to evaluate the cellular behaviors on these biomimetic coatings. Cell morphologies on the surfaces of PLLA scaffolds, PLLA scaffold...
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